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Radiothra seule taux cumulatif de rechute 15 ans: 54 % (Petersen PM, Proc ASCO 2004) - Radiothrapie + polychimiothrapie contrle excellent de la maladie (Seymour JF, JCO 2003) - tude en cours comparant radiothrapie / radiothrapie + chimiothrapie. - PET Scanner : intrt majeur (ASH 2004). " d ffg--,g--g--     3f3ff___PPT10i.x\pm^+D=' = @B +"D  K C @+ (  -   x`0e0e?Rectangle 2T<  0 aLYMPHOMES FOLLICULAIRES (3 b   x 0e0e?Rectangle 3 0 62/ formes de forte masse tumorale : CHOP-B est suprieure l endoxan en terme de SG et SSP (CALGB Peterson BA, JCO 2003) Fluda = polychimiothrapie, mais : . Plus de toxicit (ECOG, hochster Proc ASCO 2004) . Difficult de recueil de CSP (ASH 2004) Rituximab + chimiothrapie traitement pts %Rep %RC TTP Hiddeman (6-8)CHOP 102 2,6 ans Blood 2003 R(6-8) CHOP 159 NA (P<0,0007) Marcus R 8CVP 159 57%* 10%* 15 mois* Blood 2005 8R-CVP 162 81% 41% 32 mois * P< 0,0001 2$ Z -Zb Z -Zy Z -Z----< ; F M lB  D?Line 4  lB  D?Line 5  lB  D?Line 6 3f3ff___PPT10i.^+D=' = @B +"3 :2P (   -   x0e0e?Rectangle 2 `j  0 aLYMPHOMES FOLLICULAIRES (3    x0e0e?Rectangle 3q 0  - Rituximab en maintenance maintenance EFS tous pts EFS pts de novo Ghielmini M oui 23 mois 32 SAKK-Blood 2004 non 12 19 p 0,025 0,009  $ /@5 qlB  D?Line 4PPlB  D?Line 6PP 3f3ff___PPT10i. ^/+D=' = @B +" `$(  $D $  x`0e0e?Rectangle 4Z 0 xLYMPHOMES FOLLICULAIRES 0 (3 $ $  x@B0e0e?Rectangle 6zTb 0>6___PPT9  Anticorps radiomarque : Tositumomab& & & Rponse objective dans 60 80 % (RC:20 50) tude amricaine en cours. Auto en premire ligne GOELAM : (Deconinck  Blood 2004 -a): L auto diminue les rechutes(SSR) mais n allonge pas la survie Pas de bnfice net ( -K  -f   ]h   3f3ff___PPT10i.z\0I+D=' = @B +"   p((  (. (  x B0e0e?Rectangle 2 `}  0 bLYMPHOMES FOLLICULAIRES  (3  (  x B0e0e?Rectangle 3 0 Recommendations LNH folliculaire + forte masse tumorale + ge < 75 ans 6-8 cures Rituximab + polychimiothrapie (polychimio = CHOP, CEOP, mini CEOP, CVP) Rituximab en maintenance (4 injections) peut tre propos. Pas d auto en premire ligne 7 * , " <  "  f7  3f3ff___PPT10i.{\ +D=' = @B +"v }u,](  ,; ,  x B0e0e?Rectangle 2,}  0 o%LYMPHOMES FOLLICULAIRES EN RECHUTE & & 3 &n ,  x B0e0e?Rectangle 3 0 0facteurs pronostiques la premire rechute (SFH 2002) RR P Pas d autogreffe 1,7 0,02 Age la rechute > 50 ans 1,6 0,005 Forte masse tumorale 1,5 0,01 Progression < 3 ans 1,4 0,09 Progression sous traitement 1,4 0,008 DW P P+ff lB , D?Line 4CC 3f3ff___PPT10i.]+D=' = @B +" 0(  09 0  x`PF0e0e?Rectangle 2}  0 m#LYMPHOMES FOLLICULAIRES EN RECHUTE $ $ 3 $% 0  x QF0e0e?Rectangle 3 ` 0 Yfacteurs dcisionnels (SFH 2002) Age du patient (> 65 ans) Traitement initial Masse tumorale la rechute (LDH,taille des ganglions, symptmes cliniques) Intervalle entre le diagnostic et la progression Histologie la progressionD"  !ff  3f3ff___PPT10i.^+D=' = @B +"  4g(  4A 4  xSF0e0e?Rectangle 2 `  0 uLNH Folliculaires :4 $3((3  4  x@RF0e0e?Rectangle 3 0vn___PPT9PH (B) Traitement des formes rfractaires et des rechutes Monochimiothrapie orale : chlorambucal : 30 - 50 % rponse - Polychimiothrapie utilise : CHOP ou quivalent, Fluda + Endoxan (Sacchi, Biological Thrapy of Lymphoma 2003). Fluda + Endoxan + Novantrone (Forstpointer, Blood 2004) Rituximab est bnfique : Rponse (94 % VS 70 % P = 0,011) RC (40 % VS 23 %) Survie sans progression , P = 0,0139 + Survie globale : 90 % , VS : 70 % , P = 0,0943 (Forstpointer, Blood 2004). 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Bien que histologiquement, ils font partie des lymphomes de bas grade,ils ne sont plus classs dans les lymphomes indolents dans la classification de l OMS, vu leur volution souvent rapide. 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